The covered knee injection series
After an evaluation and a start on physical therapy, the next step in the program is one your insurance is built to pay for: a series of knee injections, up to five per knee, usually allowed about twice a year.
Where the series sits in the program
The program runs in a fixed order: consultation and diagnostics, then physical therapy, then the injection series. For many patients the injections bring real relief, and that relief is temporary — which is why they are used alongside therapy, to make the exercise possible, rather than instead of it.
Everything on this step is on the insurance side of the program. The orthobiologic procedures are a separate, cash-pay step for patients who want to try more before considering surgery.
The injections in the series
Corticosteroid (cortisone). An anti-inflammatory medication placed into the joint. The ACR’s 2026 update to its osteoarthritis guideline strongly recommends intra-articular corticosteroid injection for knee osteoarthritis. The effect is temporary, and repeat injections into the same joint are limited.
Hyaluronic acid (gel, viscosupplementation). A gel-like substance related to a natural component of joint fluid, usually given as a course of weekly injections. Guideline bodies disagree about it: the ACR’s 2026 update conditionally recommends against it for knee osteoarthritis, while many insurers still cover it. We will tell you where the evidence stands before you decide.
Other covered injections are used when your findings call for them. Injections are placed under in-office ultrasound guidance when that is useful. For a plain-English comparison of every knee injection, read knee injections: what each one is.
How the series and the limits work
- Up to five injections per knee in a series, depending on the injection used
- Each knee has its own series
- Most plans allow a series about twice a year — roughly every six months
- Some plans require an X-ray, a trial of physical therapy or prior authorization first
- We verify your plan’s rules and the date of your last covered series before booking
What happens at reassessment
We compare the same measurements taken at your first visit. If the knee is doing well, the plan continues. If the relief is not lasting, we do not simply repeat the series — we talk through the next options: the cash-pay orthobiologic procedures we perform here, an evaluation for genicular artery embolization, or a surgical opinion. The aim is to try everything reasonable before surgery, and to coordinate your care whichever way you go.
PRP, PPP, BMAC, and A2M are autologous procedures prepared from your own blood or bone marrow. They are considered investigational and are not FDA-approved for the treatment of any specific orthopedic condition, including osteoarthritis. Individual results are not guaranteed. Any decision to pursue an orthobiologic procedure should be made with your provider after a clinical evaluation.
Knee injection FAQs
Find out what your plan covers
Book an evaluation at our Addison clinic, or call and we’ll verify your insurance before you come in.
